生物打印在神经外科领域中的研究进展(3)
三、总结与展望
针对神经外科研究领域的脑部肿瘤治疗,通过建立脑肿瘤模型研究微环境变化下肿瘤的细胞行为学、肿瘤-血管发生机制等;在颅骨、神经以及血管等组织再生方面,尤其是在个性化定制、复杂或精细的组织结构,可实现组织修复的结构仿生;同时,生物3D打印技术能够满足活细胞以及活性物质等作为打印材料,通过选用不同的生物材料以及细胞类型或配比等实现组分仿生,进而对功能进行调控,实现最终的功能仿生。目前,基于生物3D打印技术在体外三维组织或器官模型、模拟病理微环境以及药理模型等方面已经有很大研究,未来有望为再生医学、肿瘤治疗研究、新药研发等领域的研究及产业转化带来更多机遇。
[1]徐弢.3D打印技术在生物医学领域的应用[J].中华神经创伤外科电子杂志,2015,1(1):57-58.
[2]Moroni L,Boland T,Burdick JA,et :a guide to technology and terminology[J].Trends Biotechnol,2018,36(4):384-402.
[3]Jessop ZM,Al-Sabah A,Gardiner MD,et al.3D bioprinting for reconstructive surgery:principles,applications and challenges[J].JPlast Reconstr Aesthet Surg,2017,70(9):1155-1170.
[4]Mashiko T,Konno T,Kaneko N,et in brain retraction using a self-made three-dimensional model[J].World Neurosurg,2015,84(2):585-590.
[5]Kimura T,Morita A,Nishimura K,et of and training for cerebral aneurysm clipping with 3-dimensional models[J].Neurosurgery,2009,65(4):719-725;discussion 725-726.
[6]Tai BL,Rooney D,Stephenson F,et of a 3Dprinted external ventricular drain placement simulator:technical note[J].JNeurosurg,2015,123(4):1070-1076.
[7]Lan Q,Chen A,Zhang T,et of 3D printed craniocerebral models for simulated neurosurgery[J].World Neurosurg,2016,91:434-442.
[8]Wang X,Dai X,Zhang X,et al.3D bioprinted glioma cell-laden scaffolds enriching glioma stem cells via epithelial-mesenchymal transition[J].JBiomed Mater Res A,2019,107(2):383-391.
[9]Wang X,Li X,Dai X,et of glioma stem cells improves their endotheliogenic potential[J].Colloids Surf B Biointerfaces,2018,171:629-637.
[10]Wang X,Li X,Dai X,et extrusion bioprinted shellcore hydrogel microfibers mimic glioma microenvironment and enhance the drug resistance of cancer cells[J].Colloids Surf B Biointerfaces,2018,171:291-299.
[11]Wang X,Dai X,Zhang X,et of glioma stem celllikecellson 3Dporous scaffolds composed of differentextracellular matrix[J].Biochem Biophys Res Commun,2018,498(4):1052-1057.
[12]Yi HG,Jeong YH,Kim Y,et al.A bioprinted humanglioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy[J].Nat Biomed Eng,2019,3(7):509-519.
[13]Kang HW,Lee SJ,Ko IK,et al.A 3D bioprinting system to produce human-scale tissue constructs with structural integrity[J].Nat Biotechnol,2016,34(3):312-319.
[14]Chen H,Zhang J,Li X,et customized 3D printing for autogenous implants in skull tissue engineering[J].Biofabrication,2019,11(4):0.
[15]Hu Y,Wu Y,Gou Z,et of cellularized conduits for peripheral nerve regeneration[J].Sci Rep,2016,6:.
[16]Yurie H,Ikeguchi R,Aoyama T,et al.The efficacy of a scaffoldfree Bio 3D conduit developed from human fibroblasts on peripheralnerve regeneration in a rat sciatic nerve model[J].PLoS One,2017,12(2):e0.
[17]Johnson BN,Lancaster KZ,Zhen G,et al.3D printed anatomical nerve regeneration pathways[J].Adv Funct Mater,2015,25(39):6205-6217.
[18]Koffler J,Zhu W,Qu X,et 3D-printed scaffolds for spinal cord injury repair[J].Nat Med,2019,25(2):263-269.
[19]Li X,Liu L,Zhang X,et and development of 3D printed vasculature constructs[J].Biofabrication,2018,109(3):0.
[20]Kolesky DB,Truby RL,Gladman AS,et al.3D bioprinting of vascularized,heterogeneous cell-laden tissue constructs[J].Adv Mater,2014,26(19):3124-3130.
[21]Grigoryan B,Paulsen SJ,Corbett DC,et networks and functional intravascular topologies within biocompatible hydrogels[J].Science,2019,364(6439):458-464.
[22]Skylar-Scott MA,Uzel SGM,Nam LL,et of organ-specific tissues with high cellular density and embedded vascularchannels[J].Sci Adv,2019,5(9):eaaw2459.
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